(1S,3R,4R)-(+)-3-[(tert-Butoxycarbonyl)amino]-4-hydroxycyclohexanecarboxylicacidethylester
(1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester
CAS: 365997-33-7
Molecular Formula: C14H25NO5
(1S,3R,4R)-(+)-3-[(tert-Butoxycarbonyl)amino]-4-hydroxycyclohexanecarboxylicacidethylester - Names and Identifiers
(1S,3R,4R)-(+)-3-[(tert-Butoxycarbonyl)amino]-4-hydroxycyclohexanecarboxylicacidethylester - Physico-chemical Properties
| Molecular Formula | C14H25NO5 |
| Molar Mass | 287.352 |
| Density | 1.12±0.1 g/cm3(Predicted) |
| Boling Point | 406.6±45.0 °C(Predicted) |
| Storage Condition | Room Temprature |
| Physical and Chemical Properties | Acidity coefficient (pKa) 11.73±0.60(Predicted) |
(1S,3R,4R)-(+)-3-[(tert-Butoxycarbonyl)amino]-4-hydroxycyclohexanecarboxylicacidethylester - Introduction
Ethyl (1S,3R,4R)-3-(Boc-aMino)-amino acid ester((1S,3R,4R)-3-(Boc-amino)-4-hydroxycyclohexanecarboxylate) is an organic compound with the following properties:
1. Appearance: Usually colorless or white crystalline solid.
2. melting point: about 50-55 ℃.
3. molecular formula: C, H, NO, and.
4. Molecular weight: 290.37g/mol.
This intermediate is mainly used for the preparation of edoxaban A salt, which is an antiepileptic drug. It is used as a precursor of edu xaban A salt, and the Boc protecting group can be removed by hydrolysis reaction to generate the active compound.
The preparation method can be carried out through the following steps:
1. The Boc-amino group is reacted with ethyl cyclohexenoate under appropriate conditions to produce ethyl cyclohexanecarboxylate having a Boc protecting group.
2. hydrolysis reaction is carried out under alkaline conditions to remove Boc protecting group to generate (1S,3R,4R)-3-(Boc-aMino)-acid ethyl ester.
Regarding safety information, due to the risks and hazards of chemicals, the following are some recommended considerations:
1. Avoid inhalation, ingestion or skin contact with the compound and wear personal protective equipment if necessary.
2. Good laboratory practices and safe operating procedures should be followed during operation.
3. If there is any accident or discomfort, stop using it immediately and seek medical help.
4. In addition, the compound should be stored in a cool and dry place, away from fire and oxidizing agents, and ensure that the storage container is well sealed.
1. Appearance: Usually colorless or white crystalline solid.
2. melting point: about 50-55 ℃.
3. molecular formula: C, H, NO, and.
4. Molecular weight: 290.37g/mol.
This intermediate is mainly used for the preparation of edoxaban A salt, which is an antiepileptic drug. It is used as a precursor of edu xaban A salt, and the Boc protecting group can be removed by hydrolysis reaction to generate the active compound.
The preparation method can be carried out through the following steps:
1. The Boc-amino group is reacted with ethyl cyclohexenoate under appropriate conditions to produce ethyl cyclohexanecarboxylate having a Boc protecting group.
2. hydrolysis reaction is carried out under alkaline conditions to remove Boc protecting group to generate (1S,3R,4R)-3-(Boc-aMino)-acid ethyl ester.
Regarding safety information, due to the risks and hazards of chemicals, the following are some recommended considerations:
1. Avoid inhalation, ingestion or skin contact with the compound and wear personal protective equipment if necessary.
2. Good laboratory practices and safe operating procedures should be followed during operation.
3. If there is any accident or discomfort, stop using it immediately and seek medical help.
4. In addition, the compound should be stored in a cool and dry place, away from fire and oxidizing agents, and ensure that the storage container is well sealed.
Last Update：2024-04-09 20:52:54
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Product Name: (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester Visit Supplier Webpage Request for quotation
CAS: 365997-33-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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CAS: 365997-33-7
Tel: 18301782025
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QQ: 3008007409
Wechat: 18301782025
Product Name: (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester Request for quotation
CAS: 365997-33-7
Tel: 021-60290089
Email: dshs21@eagle-pharm.com
Mobile: 18701839918
QQ: 2965663228Send QQ message
CAS: 365997-33-7
Tel: 021-60290089
Email: dshs21@eagle-pharm.com
Mobile: 18701839918
QQ: 2965663228
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